Nomenclature for factors of the HLA system update February 2008

Compiled by Steven G. E. Marsh
for the WHO Nomenclature Committee
for Factors of the HLA System.

Published In:
Tissue Antigens (2008) 71 582-584
Human Immunology (2008) 69 317-319
International Journal of Immunogenetics (2008) 35 345-346

The following sequences have been submitted to the Nomenclature Committee since the January 2008 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at :
www.ebi.ac.uk/imgt/hla/

Table 1 : New Sequences

Table 2 : Confirmatory Sequences

Table 3 : Recently Published Sequences

References:

1. Lazaro AM, Xiao Y, Cao K, et al. Thirty-two novel HLA-A alleles identified during intermediate resolution testing. Tissue Antigens. 2008;71:165-8.
2. Kwon OJ, Oh Y, Oh JW, Seo KH, Park C. A new HLA-A*24 variant, A*2475, identified by sequence-based typing in the Korean population. Tissue Antigens. 2008;71:175-6.
3. Roman A, Cervera I, Head J, Rodriguez M, Martinez-Laso J. Generation of HLA-B*1516/B*1567/B*1595 and B*1517 alleles (B15 specific group) by transpecies evolution. Hum Immunol. 2007;68:1001-8.
4. Chen MJ, Chu CC, Shyr MH, Lin PY, Yang KL. Discovery of HLA-B*480102 in Taiwanese. Int J Immunogenet. 2008;35:15-8.
5. Canossi A, Liberatore G, Del Beato T, Piazza A, Adorno D. Identification of the very uncommon allele HLA-Cw*0716 in a Caucasian renal transplant recipient: extension of the exon 4 sequence. Tissue Antigens. 2008;71:176-8.
6. Thompson EM, Kashi ZM, Martin RK, Alcorn JL, Tidey L. Identification of the novel HLA-C allele Cw*0751. Tissue Antigens. 2008;71:178-9.
7. Balas A, Bustamante L, Garcia-Sanchez F, Vicario JL. Sequencing of a novel HLA-DRB1*07 allele with a new polymorphism at amino acid position 21 (DRB1*0715). Tissue Antigens. 2008;71:179-80.
8. Zhao W, Guerrero E, Kerman RH, Cano P, Fernandez-Vina MA. DRB1*1613N: a novel DRB1 allele with a premature termination codon. Tissue Antigens. 2008;71:180-2.

Address for correspondence:

Steven G. E. Marsh
Anthony Nolan Research Institute
Royal Free Hospital
Pond Street
London NW3 2QG
United Kingdom

Tel. (44) 20 7284 8321
Fax. (44) 20 7284 8331

© email: Steven G. E. Marsh