Nomenclature for factors of the HLA system update March 2008

Compiled by Steven G. E. Marsh
for the WHO Nomenclature Committee
for Factors of the HLA System.

Published In:
Tissue Antigens (2008) in press
Human Immunology (2008) in press
International Journal of Immunogenetics (2008) 35 347-348

The following sequences have been submitted to the Nomenclature Committee since the February 2008 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at :
www.ebi.ac.uk/imgt/hla/

Table 1 : New Sequences

Sequence	Cell Identification	Accession Number	Submitting Author
A*02010103	HSR131658	AM943368	Hien Tran, Heidelberg, Germany
A*020606	JMDP01K001	AB427093	Kenji Tadokoro, Tokyo, Japan
A*2486N	HZB10788	EF062307	Lixing Yan, Hangzhou, China
A*3122	012948	EU580147	Jianping Li, Shenyang, Liaoning, China
A*3316	OLMEMIGU01	EU480687	Peter Stastny, Dallas, Texas, USA
A*3317	ZJCB5940	EU554565	Lixing Yan, Hangzhou, China
A*9241	CS00001, CS00002	EU559334, EU559335	Kai Cao, Los Angeles, USA
B*072202	BY00278	EU522472	Carolyn K Hurley, Washington DC, USA
B*0764	BY00282	EU522468	Carolyn K Hurley, Washington DC, USA
B*0836	BY00283	EU522467	Carolyn K Hurley, Washington DC, USA
B*1408	BY00286	EU555330	Carolyn K Hurley, Washington DC, USA
B*1829	BY00281	EU522469	Carolyn K Hurley, Washington DC, USA
B*2741	BY00298	EU555320	Carolyn K Hurley, Washington DC, USA
B*2742	BY00292	EU555325	Carolyn K Hurley, Washington DC, USA
B*350107	CS00004	EU564807	Kai Cao, Los Angeles, USA
B*356802	BY00280, BY00295	EU522470, EU555322	Carolyn K Hurley, Washington DC, USA
B*391902	BY00299	EU555319	Carolyn K Hurley, Washington DC, USA
B*4087	BY00271	EU522479	Carolyn K Hurley, Washington DC, USA
B*4088	ZJCB5764	EU554563	Lixing Yan, Hangzhou, China
B*4460	BY00274	EU522476	Carolyn K Hurley, Washington DC, USA
B*4508	BY00273	EU522477	Carolyn K Hurley, Washington DC, USA
B*4614	ZJCB5857	EU554564	Lixing Yan, Hangzhou, China
B*510109	BY00302	EU555316	Carolyn K Hurley, Washington DC, USA
B*512402	07-2151	EU547797	Kyung-won Kim, Seoul, South Korea
B*5153	BY00297	EU555321	Carolyn K Hurley, Washington DC, USA
B*5154	BY00291	EU555326	Carolyn K Hurley, Washington DC, USA
B*5155	BY00287	EU555329	Carolyn K Hurley, Washington DC, USA
B*5212	EPM-17177	EU517716	Gisele Rampim, Sao Paulo, Brazil
B*5316	BY00300	EU555318	Carolyn K Hurley, Washington DC, USA
B*5622	BY00284	EU522466	Carolyn K Hurley, Washington DC, USA
B*5623	BY00272	EU522478	Carolyn K Hurley, Washington DC, USA
B*5817N	BY00303	EU564105	Carolyn K Hurley, Washington DC, USA
B*8104N	BY00279	EU522471	Carolyn K Hurley, Washington DC, USA
B*9543	BY00285	EU522465	Carolyn K Hurley, Washington DC, USA
B*9544	CTJ-18300	EU547493	Lina Yan, Tianjin, China
B*9545	BY00288	EU555328	Carolyn K Hurley, Washington DC, USA
B*9546	CS00003	EU564806	Kai Cao, Los Angeles, USA
B*9546	HCP-95	AM711637	Oscar de la Calle-Martin, Barcelona, Spain
Cw*0221	Scu00977	EU499385	Francisco de Paula Sanchez Gordo, Malaga, Spain
Cw*0617	SJ280/32	AM285029	Gottfried Fischer, Vienna, Austria
Cw*0816	FBCCB5992	AB426906	Yukari Kuroda, Fukuoka, Japan
Cw*120306	LUMC-C46	AM946387	Jacqy DH Anholts, Leiden, The Netherlands
DRB1*150205	P2976	EU523122	Lixing Yan, Hangzhou, China
MICA*056	MYUL82208AN	AM944063	Ann-Margaret Little, London, United Kingdom

Table 2 : Confirmatory Sequences

Sequence	Cell Identification	Accession Number	Submitting Author
A*290201	HSR131658	AM944568	Hien Tran, Heidelberg, Germany
B*0724	BY00293	EU555324	Carolyn K Hurley, Washington DC, USA
B*1312	Scu3556m	EU516353	Francisco de Paula Sanchez Gordo, Malaga, Spain
B*1556	BY00302	EU555315	Carolyn K Hurley, Washington DC, USA
B*270507	LUMC-B49	AM946390	Jacqy DH Anholts, Leiden, The Netherlands
B*352001	Scu03771m	EU516354	Francisco de Paula Sanchez Gordo, Malaga, Spain
B*3537	LUMC-B48	AM946389	Jacqy DH Anholts, Leiden, The Netherlands
B*391301	C2035U	EU499386	Francisco de Paula Sanchez Gordo, Malaga, Spain
B*3931	LUMC-B3	AM746506	Jacqy DH Anholts, Leiden, The Netherlands
B*4080	BY00276	EU522474	Carolyn K Hurley, Washington DC, USA
B*4421	Scu03903	EU499387	Francisco de Paula Sanchez Gordo, Malaga, Spain
B*4450	BY00294	EU555323	Carolyn K Hurley, Washington DC, USA
B*5140	BY00289	EU555327	Carolyn K Hurley, Washington DC, USA
B*5714	BY00275	EU522475	Carolyn K Hurley, Washington DC, USA
B*9541	BY00277, BY00301	EU522473, EU555317	Carolyn K Hurley, Washington DC, USA
DRB1*1477	CTJ-18807	EU545181	Lina Yan, Tianjin, China

Table 3 : Recently Published Sequences

Sequence	References
B*4073	(1)
B*4075	(2)
B*5714	(3)
B*9529	(4)
B*9534	(5)
G*010114	(6)
DRB1*0465	(7)

References:

Kwon OJ, Kim J, Dirisala VR, Xiao R, Park C. A new HLA-B*40 variant, B*4073, identified by sequence-based typing in the Korean population. Tissue Antigens. 2008;71:250-1.
Wang D, Zhang Z. Characterization of the novel allele HLA-B*4075. Tissue Antigens. 2008;71:251-2.
Altermann WW, Grondkowski V, Reichert S, Seliger B, Schlaf G. A novel HLA-B*57 (B*5714) allele in a healthy male Caucasian individual. Tissue Antigens. 2008;71:253-4.
Zhu FM, He J, Zhang W, Yan LX. Identification of a novel HLA-B*15 allele, B*9529, in the Chinese population. Tissue Antigens. 2008;71:254-5.
Yan LX, Zhu FM, He JJ, Xu XG. A novel HLA-B*15 allele, B*9534, identified by sequence-based typing in the Chinese population. Tissue Antigens. 2008;71:256-7.
Arnaiz-Villena A, Serrano-Vela JI, Reguera R, Perez-Saborido B, Moreno E, Moscoso J. A novel allele, HLA-G*010114, with a non-coding DNA base change in exon 2. Tissue Antigens. 2008;71:258-9.
Witter K, Mautner J, Volgger A, Zahn R, Kauke T. A novel HLA-DRB1 allele, HLA-DRB1*0465, was identified in a Hodgkin's lymphoma cell line. Tissue Antigens. 2008;71:257-8.

Address for correspondence:

Steven G. E. Marsh
Anthony Nolan Research Institute
Royal Free Hospital
Pond Street
London NW3 2QG
United Kingdom

Tel. (44) 20 7284 8321
Fax. (44) 20 7284 8331