Nomenclature for factors of the HLA system update April 2008

Compiled by Steven GE Marsh
for the WHO Nomenclature Committee
for Factors of the HLA System.

Published In:
Tissue Antigens (2008) 72 221-223
Human Immunology (2008) 69 526-528
International Journal of Immunogenetics (2008) 35 349-351

The following sequences have been submitted to the Nomenclature Committee since the March 2008 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at :
www.ebi.ac.uk/imgt/hla/

Table 1 : New Sequences

Sequence	Cell Identification	Accession Number	Submitting Author
A*112402	JMDP01K007	AB430468	Kenji Tadokoro, Tokyo, Japan
A*240216	JMDP01K008	AB434096	Kenji Tadokoro, Tokyo, Japan
A*2636	CHA06-0792	EU557970	HyeYoung Seong, Seongnam, South Korea
A*2636	016149	EU627183	Jianping Li, Shenyang, Liaoning, China
A*2637	0200800714	AM981205	Silvia Ulrich, Graz, Austria
A*3025	0004123	EU623422	Francisco de Paula Sanchez Gordo, Malaga, Spain
A*9242	JMDP01K002	AB427094	Kenji Tadokoro, Tokyo, Japan
A*9243	JMDP01K003	AB429008	Kenji Tadokoro, Tokyo, Japan
A*9244	JMDP01K004	AB429218	Kenji Tadokoro, Tokyo, Japan
A*9245	BJ54	EU649706	Zhixin Zhang, Beijing, China
B*0765	LUMC-B47	AM946388	Jacqy DH Anholts, Leiden, The Netherlands
B*1322	BY00309	EU643607	Carolyn K Hurley, Washington DC, USA
B*1409	BY00313	EU643603	Carolyn K Hurley, Washington DC, USA
B*152703	SZ-13	EU617016	Hong-Yan Zou, Shenzhen, China
B*2743	BY00318	EU643598	Carolyn K Hurley, Washington DC, USA
B*3589	VTIS163461	EU589203	Maude Phipps, Kuala Lumpur, Malaysia
B*3590	BY00316	EU643600	Carolyn K Hurley, Washington DC, USA
B*3591	BY00319	EU643597	Carolyn K Hurley, Washington DC, USA
B*390105	BY00306	EU643610	Carolyn K Hurley, Washington DC, USA
B*4089	DEDKM740290	AM980943	Anne Dormoy, Strasbourg, France
B*4090	BY00304	EU643612	Carolyn K Hurley, Washington DC, USA
B*4509	MO-19507	EU517717	Gisele Rampim, Sao Paulo, Brazil
B*5156	BY00305	EU643611	Carolyn K Hurley, Washington DC, USA
B*5213	BY00312	EU643604	Carolyn K Hurley, Washington DC, USA
B*5531	BY00317	EU643599	Carolyn K Hurley, Washington DC, USA
B*5717	BY00315	EU643601	Carolyn K Hurley, Washington DC, USA
B*5818	BY00310	EU643605	Carolyn K Hurley, Washington DC, USA
B*9547	BY00314	EU643602	Carolyn K Hurley, Washington DC, USA
Cw*0121	SZ-12	EU617015	Zhen Li, Shenzhen, China
Cw*0755N	MHHZ-00020178	AM945965	Rainer Blasczyk, Hannover, Germany
Cw*0756	BJ53	EU594580	Zhixin Zhang, Beijing, China
DRB1*0474	SI772	AM947655	Jean-Marie Tiercy, Geneva, Switzerland
DRB1*0907	AS2054	AM947068	Xiang Liu, Beijing, China
DRB1*1478	HistoCB69685	EU588391	Hoon Han, Seoul, South Korea
DRB1*1479	NT00788	EU643616	Carolyn K Hurley, Washington DC, USA
DQB1*0322	175842	AM944346	Klaus Witter, München, Germany
DQB1*060104	BJ52	EU594579	Zhixin Zhang, Beijing, China

Table 2 : Confirmatory Sequences

Sequence	Cell Identification	Accession Number	Submitting Author
A*0260	BRABRI	EU580406	Youri Serov, Indianapolis, USA
A*0276	JMDP01K005	AB429497	Kenji Tadokoro, Tokyo, Japan
A*1113	JMDP01K006	AB430331	Kenji Tadokoro, Tokyo, Japan
B*0742	4229311	AM931289	Laura Hammond, Auckland, New Zealand
B*1825	BY00321	EU643595	Carolyn K Hurley, Washington DC, USA
B*356802	BY00296	EU557367	Carolyn K Hurley, Washington DC, USA
B*4059	BY00307	EU643609	Carolyn K Hurley, Washington DC, USA
B*4064	BY00320	EU643596	Carolyn K Hurley, Washington DC, USA
B*4209	BY00308	EU643608	Carolyn K Hurley, Washington DC, USA
B*5155	BY00290	EU557368	Carolyn K Hurley, Washington DC, USA
B*5315	BY00311	EU643606	Carolyn K Hurley, Washington DC, USA
DRB1*0441	NT00791	EU643613	Carolyn K Hurley, Washington DC, USA
DRB1*1121	NT00790	EU643614	Carolyn K Hurley, Washington DC, USA
DRB1*1304	40267	AM949862	Thibaut Gervais, Brussels, Belgium
DRB1*1474	39756	AM982721	Thibaut Gervais, Brussels, Belgium
DRB1*1524	NT00789	EU643615	Carolyn K Hurley, Washington DC, USA

Table 3 : Recently Published Sequences

Sequence	References
A*0339	(1)
A*240215	(2)
A*310103	(3)
A*9216	(4)
A*9237	(5)
B*0745	(6)
B*0826	(6)
B*0828	(7)
B*0831	(6)
B*2731	(6)
B*350106	(6)
B*350402	(6)
B*3566	(6)
B*356801	(6)
B*370102	(6)
B*3711	(6)
B*380102	(6)
B*3813	(6)
B*3935	(6)
B*3939	(6)
B*4108	(6)
B*4209	(6)
B*4444	(6)
B*4448	(6)
B*480302	(6)
B*4815	(6)
B*5140	(6)
B*5411	(8)
B*5523	(6)
B*5529	(9)
B*5617	(6)
B*570103	(6)
B*5710	(6)
B*9505	(6)
B*9510	(6)
B*9519	(6)
B*9531	(3)
G*010113	(10)
DRB1*116502	(11)
DQB1*0634	(12)

References:

1. Balas A, Garcia-Sanchez F, Bustamante L, Vicario JL. New HLA-A allele, A*0339, identified in a Spanish patient. Tissue Antigens. 2008;71:478.

2. Emmerich F, Schonemann C, Hartmann S, Salama A. Identification of the novel HLA-A*240215 allele by haplotype-specific sequencing. Tissue Antigens. 2008;71:481-2.

3. Frison S, Longhi E, Andreini E, Poli F, Scalamogna M. Characterization of two novel HLA class I alleles: HLA-A*310103 and HLA-B*9531. Int J Immunogenet. 2008;35:193-5.

4. Jiang W, Zhang JQ, Pan N, Xu JH, Xie W. Identification of a novel HLA-A allele, HLA-A*9216. Tissue Antigens. 2008;71:479-80.

5. Kelsch R, Binder TM, Sibrowski W. Identification of the novel allele HLA-A*9237 in peripheral blood of a bone marrow donor. Tissue Antigens. 2008;71:480-1.

6. Lazaro AM, Xiao Y, Cao K, et al. Expanding diversity at the HLA-B locus: 28 novel HLA-B alleles. Tissue Antigens. 2008;71:471-4.

7. Brixner V, Richter R, Bader P, Seifried E, Seidl C. A new HLA-B*08 allele, HLA-B*0828, found in two voluntary stem cell donors. Tissue Antigens. 2008;71:482-3.

8. Yan LN, Li SY, Dong Z, et al. Identification of a novel HLA-B*54 allele, B*5411, by sequence-based typing in a Chinese individual. Tissue Antigens. 2008;71:484-5.

9. Emmerich F, Schonemann C, Galicki L, Salama A. Identification of a novel HLA-B allele, HLA-B*5529, by haplotype-specific sequencing. Tissue Antigens. 2008;71:486.

10. Kang H, Yun HS, Lee JK, Kwack K. Identification of a novel HLA-G allele, HLA-G*010113, in a Korean individual. Tissue Antigens. 2008;71:492-4.

11. Serov Y, Hommel-Berrey G, Lobashevsky A. Identification of a novel HLA-DRB1 allele, DRB1*116502, by sequence-based typing in an African-American individual. Tissue Antigens. 2008;71:489-90.

12. Witter K, Albert T, Zahn R, Kauke T. HLA-DQB1*0634, a novel DQB1 allele found by high-resolution HLA typing of a sibling pair for potential bone marrow transplantation. Tissue Antigens. 2008;71:486-8.

Address for correspondence:

Steven GE Marsh
Anthony Nolan Research Institute
Royal Free Hospital
Pond Street
London NW3 2QG
United Kingdom

Tel. (44) 20 7284 8321
Fax. (44) 20 7284 8331