a summary of HLA-A, -B, -C, -DRB1/3/4/5 and -DQB1 alleles and theirassociation with serologically defined HLA-A, -B, -C, -DR and -DQantigens
G.M.Th. Schreuder, C.K. Hurley, S.G.E. Marsh, M. Lau,M. Fernandez-Vina, H.J. Noreen, M. Setterholm, M. Maiers.
Published in:
Tissue Antigens (2005) 65 1-55
Human Immunology (2005) 66 170-210
International Journal of Immunogenetics (2005) 32 19-69
A copy of this report in PDF format as published in Tissue Antigens is available courtesy of Blackwell Publishing, © Blackwell Munksgaard 2005
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Abstract
This report presents serologic equivalents of humanleucocyte antigen (HLA)-A, -B, -C, -DRB1, -DRB3, -DRB4, -DRB5 and -DQB1alleles. The dictionary is an update of the one published in 2001. Thedata summarize equivalents obtained by the World Health OrganizationNomenclature Committee for factors of the HLA System, the InternationalCell Exchange, the National Marrow Donor Program, recent publicationsand individual laboratories. This latest update of the dictionary isenhanced by the inclusion of results from studies performed during the13th International Histocompatibility Workshop and from neural network analyses. A summary of the data as recommended serologic equivalents ispresented as expert assigned types. The tables include remarks foralleles, which are or may be expressed as antigens with serologicreaction patterns that differ from the well-established HLAspecificities. The equivalents provided will be useful in guidingsearches for unrelated hematopoietic stem cell donors in which patients and/or potential donors are typed by either serology or DNA-based methods. The serological DNA equivalent dictionary will also aid in typing and matching procedures for organ transplant programs whose waiting lists of potential donors and recipients comprise of mixtures of serologic and DNA-based typings. The tables with HLA equivalents and a questionnaire for submission of serologic reaction patterns for poorly identified allelic products will be made available through the WMDA webpage: www.worldmarrow.org. and in the near future also in a searchable form on the IMGT/HLA database.
Correspondence to:
Dr Rhonda Holdsworth
Tissue Typing Services
Australian Red Cross Blood Service, South East Region
P.O. Box354
Melbourne
Victoria3205
Australia
Tel: +61/3-9640111
Fax: +61/3-96861768
E-mail: rholdsworth@arcbs.redcross.org.au
