Haemoglobinopathies are pathological conditions relating to the red blood cells.
Thalassaemia Major
Thalassaemia Major results from a complete absence or severe reduction in the synthesis of haemoglobin - the substance in red blood cells which carries oxygen. This inherited condition leads to severe anaemia and the need for regular blood transfusions. The latter can give rise to serious iron overload and subsequent liver and cardiac failure. Currently, transplant from a related donor is recommended but not from an unrelated donor.
